Early Detection & Precision Medicine
Circulating cell-free DNA (cfDNA), cell-free RNA (cfRNA) and extracellular vesicles (EV) in body fluids provide a rich source of information with clinical value in diagnosis, prognosis, and treatment monitoring of various diseases. Our goal is to develop and deploy technologies for diagnosis, precision selection of therapy, and treatment assessment by analyzing circulating analytes such as cfRNA, cfDNA, EV and proteins in body fluids. We also seek to understand the complex environment of molecular features detected in body fluids associated with disease progression and the evolution of diseases in response to treatment.
Circulating cell-free DNA (cfDNA), cell-free RNA (cfRNA) and extracellular vesicles (EV) in body fluids provide a rich source of information with clinical value in diagnosis, prognosis, and treatment monitoring of various diseases. Our goal is to develop and deploy technologies for diagnosis, precision selection of therapy, and treatment assessment by analyzing circulating analytes such as cfRNA, cfDNA, EV and proteins in body fluids. We also seek to understand the complex environment of molecular features detected in body fluids associated with disease progression and the evolution of diseases in response to treatment.
Cell-free Nucleic Acids
We develop new methods and maximize the capacity to extract high information content of the cell-free transcriptome and epigenome. Specifically, we are interested in mRNA, circular RNA and transposable elements, microbiome, methylation and chromatin condensation. We utilize advanced development in bioinformatics, machine learning and statistical models for feature selection, classification, anomaly detection, time series analysis, pathway analysis and multiomics data integration.
Extracellular Vesicles
We develop novel methods for screening with low background, high sensitivity, high resolution and wide dynamic range to profile proteins and RNA cargos of EV, to characterize them physically and to measure them at both single EV level and at high a throughput manner. We are interested in utilizing EV in body fluids for diagnosis, prognosis and to understand the pathology of diseases. We also seek to understand the basic mechanism of EV medicated cell-cell communication, EV's content packaging and delivery.